The U.S. Chamber of Commerce submits these comments regarding the Agency for Toxic Substances and Disease Registry’s (“ATSDR” or “Agency”) 2018 draft toxicological profile (“Draft Profile”) for perfluoroalkyls (“PFAS”).1 A number of Chamber members have produced PFAS in the past and ATSDR’s Draft Profile would adversely affect them. It is imperative that Federal agencies base their policies and actions regarding PFAS on the best available science and weight of the scientific evidence...